Nicole Richie couldn’t stay composed during Thursday’s 100th episode of Grey’s Anatomy , as Izzie ( Katherine Heigl ) unexpectedly married Alex ( Justin Chambers ). Richie took to her Twitter page after the show, writing: “Just watched Grey’s & cried my f-ing eyes out.” The show definitely was emotional. Meredith ( Ellen Pompeo ) and Derek ( Patrick Dempsey ) were supposed to wed — and Izzie, who is battling a brain tumor, couldn’t wait. See which celebs have been bridesmaids in real life Even though her hair was falling out and she was seeing visions of her dead ex Denny again, she was determined to fulfill her bridesmaid duties. But after hearing news that Izzie was seeing Denny again, Derek performed an MRI and ended up finding a new, small (and inoperable) tumor.

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Nicole Richie: "I Cried My Eyes Out" Watching Izzie Wed on Grey’s